Structural characterization of copper(II) binding to α-synuclein: Insights into the bioinorganic chemistry of Parkinson's disease

The aggregation of α-synuclein (AS) is characteristic of Parkinson's disease and other neurodegenerative synucleinopathies. We demonstrate here that Cu(II) ions are effective in accelerating AS aggregation at physiologically relevant concentrations without altering the resultant fibrillar struc...

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Hauptverfasser: Rasia, Rodolfo M., Bertoncini, Carlos W., Marsh, Derek, Hoyer, Wolfgang, Cherny, Dmitry, Zweckstetter, Markus, Griesinger, Christian, Jovin, Thomas M., Fernández, Claudio O.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2005
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC555498/
https://ncbi.nlm.nih.gov/pubmed/15767574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407881102
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