Release of long-range tertiary interactions potentiates aggregation of natively unstructured α-synuclein

In idiopathic Parkinson's disease, intracytoplasmic neuronal inclusions (Lewy bodies) containing aggregates of the protein α-synuclein (αS) are deposited in the pigmented nuclei of the brainstem. The mechanisms underlying the structural transition of innocuous, presumably natively unfolded, αS...

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Main Authors: Bertoncini, Carlos W., Jung, Young-Sang, Fernandez, Claudio O., Hoyer, Wolfgang, Griesinger, Christian, Jovin, Thomas M., Zweckstetter, Markus
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2005
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC547830/
https://ncbi.nlm.nih.gov/pubmed/15671169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407146102
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