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The diamidine DB75 targets the nucleus of Plasmodium falciparum

BACKGROUND: DB289, [2,5-bis(4-amidinophenyl)furan bis-O-methylamidoxime], is a broad spectrum anti-parasitic compound which has been shown to be effective against malaria in recent clinical trials. DB75, [2,5-bis(4-amidinophenyl)furan], is the active metabolite of this drug. The objective of this st...

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Autors principals: Purfield, Anne E, Tidwell, Richard R, Meshnick, Steven R
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2689252/
https://ncbi.nlm.nih.gov/pubmed/19442305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-8-104
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