Accumulation and Intracellular Distribution of Antitrypanosomal Diamidine Compounds DB75 and DB820 in African Trypanosomes

The aromatic diamidine pentamidine has long been used to treat early-stage human African trypanosomiasis (HAT). Two analogs of pentamidine, DB75 and DB820, have been shown to be more potent and less toxic than pentamidine in murine models of trypanosomiasis. The diphenyl furan diamidine, DB75, is th...

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Detalhes bibliográficos
Main Authors: Mathis, Amanda M., Holman, Jacqueline L., Sturk, Lisa M., Ismail, Mohamed A., Boykin, David W., Tidwell, Richard R., Hall, James Edwin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1479144/
https://ncbi.nlm.nih.gov/pubmed/16723581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00192-06
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