Accumulation and Intracellular Distribution of Antitrypanosomal Diamidine Compounds DB75 and DB820 in African Trypanosomes

The aromatic diamidine pentamidine has long been used to treat early-stage human African trypanosomiasis (HAT). Two analogs of pentamidine, DB75 and DB820, have been shown to be more potent and less toxic than pentamidine in murine models of trypanosomiasis. The diphenyl furan diamidine, DB75, is th...

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Main Authors: Mathis, Amanda M., Holman, Jacqueline L., Sturk, Lisa M., Ismail, Mohamed A., Boykin, David W., Tidwell, Richard R., Hall, James Edwin
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2006
Teme:
Mechanisms of Action: Physiological Effects
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1479144/
https://ncbi.nlm.nih.gov/pubmed/16723581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00192-06
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