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The Mitochondrion Is a Site of Trypanocidal Action of the Aromatic Diamidine DB75 in Bloodstream Forms of Trypanosoma brucei

Human African trypanosomiasis (HAT) is a fatal tropical disease caused by infection with protozoans of the species Trypanosoma brucei gambiense and T. b. rhodesiense. An oral prodrug, DB289, is a promising new therapy undergoing phase III clinical trials for early-stage HAT. DB289 is metabolically c...

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Detalhes bibliográficos
Main Authors: Lanteri, Charlotte A., Tidwell, Richard R., Meshnick, Steven R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258549/
https://ncbi.nlm.nih.gov/pubmed/18086841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00642-07
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