Diphenyl Furans and Aza Analogs: Effects of Structural Modification on In Vitro Activity, DNA Binding, and Accumulation and Distribution in Trypanosomes

Human African trypanosomiasis is a devastating disease with only a few treatment options, including pentamidine. Diamidine compounds such as pentamidine, DB75, and DB820 are potent antitrypanosomal compounds. Previous investigations have shown that diamidines accumulate to high concentrations in try...

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Detalhes bibliográficos
Main Authors: Mathis, Amanda M., Bridges, Arlene S., Ismail, Mohamed A., Kumar, Arvind, Francesconi, Iris, Anbazhagan, Mariappan, Hu, Qiyue, Tanious, Farial A., Wenzler, Tanja, Saulter, Janelle, Wilson, W. David, Brun, Reto, Boykin, David W., Tidwell, Richard R., Hall, James Edwin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1932548/
https://ncbi.nlm.nih.gov/pubmed/17517831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00005-07
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