Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575

The γ-secretase complex is a major therapeutic target for the prevention and treatment of Alzheimer's disease. Previous studies have shown that treatment of young APP mice with specific inhibitors of γ-secretase prevented formation of new plaques. It has not yet been shown directly whether exis...

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Главные авторы: Garcia-Alloza, Monica, Subramanian, Meenakshi, Thyssen, Diana, Borrelli, Laura A, Fauq, Abdul, Das, Pritam, Golde, Todd E, Hyman, Bradley T, Bacskai, Brian J
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2009
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2687427/
https://ncbi.nlm.nih.gov/pubmed/19419556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-4-19
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