Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575

The γ-secretase complex is a major therapeutic target for the prevention and treatment of Alzheimer's disease. Previous studies have shown that treatment of young APP mice with specific inhibitors of γ-secretase prevented formation of new plaques. It has not yet been shown directly whether exis...

Full description

Saved in:
Bibliographic Details
Main Authors: Garcia-Alloza, Monica, Subramanian, Meenakshi, Thyssen, Diana, Borrelli, Laura A, Fauq, Abdul, Das, Pritam, Golde, Todd E, Hyman, Bradley T, Bacskai, Brian J
Format: Artigo
Language:Inglês
Published: BioMed Central 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2687427/
https://ncbi.nlm.nih.gov/pubmed/19419556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-4-19
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items