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A multigram chemical synthesis of the γ-secretase inhibitor LY411575 and its diastereoisomers
An improved chemical synthesis of N-2((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-L-alaninamide (LY411,575, 9a), a known γ-secretase inhibitor, is described. The key synthetic steps, which used no chiral chromatography in the entire...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2962444/ https://ncbi.nlm.nih.gov/pubmed/17897827 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.07.062 |
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