Rapid β-Amyloid Deposition and Cognitive Impairment after Cholinergic Denervation in APP/PS1 Mice

Although extensive evidence supports the role of amyloid-β (Aβ) in Alzheimer disease (AD), the neurotoxic mechanisms underlying AD pathogenesis are not understood. On the other hand, neuronal loss is the pathological feature that best correlates with cognitive impairment. We hypothesized that cholin...

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Hauptverfasser: Ramos-Rodriguez, Juan Jose, Pacheco-Herrero, Mar, Thyssen, Diana, Murillo-Carretero, Maria Isabel, Berrocoso, Esther, Spires-Jones, Tara L., Bacskai, Brian J., Garcia-Alloza, Monica
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612835/
https://ncbi.nlm.nih.gov/pubmed/23481704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/NEN.0b013e318288a8dd
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