Rapid β-Amyloid Deposition and Cognitive Impairment after Cholinergic Denervation in APP/PS1 Mice

Although extensive evidence supports the role of amyloid-β (Aβ) in Alzheimer disease (AD), the neurotoxic mechanisms underlying AD pathogenesis are not understood. On the other hand, neuronal loss is the pathological feature that best correlates with cognitive impairment. We hypothesized that cholin...

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Detalhes bibliográficos
Main Authors: Ramos-Rodriguez, Juan Jose, Pacheco-Herrero, Mar, Thyssen, Diana, Murillo-Carretero, Maria Isabel, Berrocoso, Esther, Spires-Jones, Tara L., Bacskai, Brian J., Garcia-Alloza, Monica
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612835/
https://ncbi.nlm.nih.gov/pubmed/23481704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/NEN.0b013e318288a8dd
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