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Phospholipase D-mediated Activation of IQGAP1 through Rac1 Regulates Hyperoxia-induced p47(phox) Translocation and Reactive Oxygen Species Generation in Lung Endothelial Cells
Phosphatidic acid generated by the activation of phospholipase D (PLD) functions as a second messenger and plays a vital role in cell signaling. Here we demonstrate that PLD-dependent generation of phosphatidic acid is critical for Rac1/IQGAP1 signal transduction, translocation of p47(phox) to cell...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2685714/ https://ncbi.nlm.nih.gov/pubmed/19366706 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.005439 |
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