Phospholipase D-mediated Activation of IQGAP1 through Rac1 Regulates Hyperoxia-induced p47(phox) Translocation and Reactive Oxygen Species Generation in Lung Endothelial Cells

Phosphatidic acid generated by the activation of phospholipase D (PLD) functions as a second messenger and plays a vital role in cell signaling. Here we demonstrate that PLD-dependent generation of phosphatidic acid is critical for Rac1/IQGAP1 signal transduction, translocation of p47(phox) to cell...

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Autores principales: Usatyuk, Peter V., Gorshkova, Irina A., He, Donghong, Zhao, Yutong, Kalari, Satish K., Garcia, Joe G. N., Natarajan, Viswanathan
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Mechanisms of Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685714/
https://ncbi.nlm.nih.gov/pubmed/19366706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.005439
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