Protein Kinase C-ε Regulates Sphingosine 1-Phosphate-mediated Migration of Human Lung Endothelial Cells through Activation of Phospholipase D2, Protein Kinase C-ζ, and Rac1

The signaling pathways by which sphingosine 1-phosphate (S1P) potently stimulates endothelial cell migration and angiogenesis are not yet fully defined. We, therefore, investigated the role of protein kinase C (PKC) isoforms, phospholipase D (PLD), and Rac in S1P-induced migration of human pulmonary...

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Detalhes bibliográficos
Main Authors: Gorshkova, Irina, He, Donghong, Berdyshev, Evgeny, Usatuyk, Peter, Burns, Michael, Kalari, Satish, Zhao, Yutong, Pendyala, Srikanth, Garcia, Joe G. N., Pyne, Nigel J., Brindley, David N., Natarajan, Viswanathan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431079/
https://ncbi.nlm.nih.gov/pubmed/18296444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800250200
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