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Alteration of enzyme specificity by computational loop remodeling and design

Altering the specificity of an enzyme requires precise positioning of side-chain functional groups that interact with the modified groups of the new substrate. This requires not only sequence changes that introduce the new functional groups but also sequence changes that remodel the structure of the...

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Bibliografske podrobnosti
Main Authors: Murphy, Paul M., Bolduc, Jill M., Gallaher, Jasmine L., Stoddard, Barry L., Baker, David
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685249/
https://ncbi.nlm.nih.gov/pubmed/19470646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811070106
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