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Alteration of enzyme specificity by computational loop remodeling and design
Altering the specificity of an enzyme requires precise positioning of side-chain functional groups that interact with the modified groups of the new substrate. This requires not only sequence changes that introduce the new functional groups but also sequence changes that remodel the structure of the...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2685249/ https://ncbi.nlm.nih.gov/pubmed/19470646 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811070106 |
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