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Computational thermostabilization of an enzyme
The thermostabilization of an enzyme while maintaining its activity for industrial or biomedical applications using traditional selection methods can be difficult. We demonstrate a rapid computational approach that identified three mutations within a model enzyme that produce a 10°C increase in appa...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2005
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3412875/ https://ncbi.nlm.nih.gov/pubmed/15879217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1107387 |
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