Yeast Cytosine Deaminase Mutants with Increased Thermostability Impart Sensitivity to 5-Fluorocytosine

Prodrug gene therapy (PGT) is a treatment strategy in which tumor cells are transfected with a 'suicide' gene that encodes a metabolic enzyme capable of converting a nontoxic prodrug into a potent cytotoxin. One of the most promising PGT enzymes is cytosine deaminase (CD), a microbial salv...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Stolworthy, Tiffany S., Korkegian, Aaron M., Willmon, Candice L., Ardiani, Andressa, Cundiff, Jennifer, Stoddard, Barry L., Black, Margaret E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2330253/
https://ncbi.nlm.nih.gov/pubmed/18291415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.01.002
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge