Yeast Cytosine Deaminase Mutants with Increased Thermostability Impart Sensitivity to 5-Fluorocytosine

Prodrug gene therapy (PGT) is a treatment strategy in which tumor cells are transfected with a 'suicide' gene that encodes a metabolic enzyme capable of converting a nontoxic prodrug into a potent cytotoxin. One of the most promising PGT enzymes is cytosine deaminase (CD), a microbial salv...

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Autores principales: Stolworthy, Tiffany S., Korkegian, Aaron M., Willmon, Candice L., Ardiani, Andressa, Cundiff, Jennifer, Stoddard, Barry L., Black, Margaret E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2330253/
https://ncbi.nlm.nih.gov/pubmed/18291415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.01.002
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