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Role of Glutamate 64 in the Activation of the Prodrug 5-fluorocytosine by Yeast Cytosine Deaminase

Yeast cytosine deaminase catalyzes the hydrolytic deamination of cytosine to uracil as well as the deamination of the prodrug 5-fluorocytosine (5FC) to the anticancer drug 5-fluorouracil. In this study, the role of Glu64 in the activation of the prodrug 5FC was investigated by site-directed mutagene...

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Hlavní autoři: Wang, Jifeng, Sklenak, Stepan, Liu, Aizhuo, Felczak, Krzysztof, Wu, Yan, Li, Yue, Yan, Honggao
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272785/
https://ncbi.nlm.nih.gov/pubmed/22208667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201540z
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