Dihydropyrimidine Dehydrogenase Is a Prognostic Marker for Mesenchymal Stem Cell-Mediated Cytosine Deaminase Gene and 5-Fluorocytosine Prodrug Therapy for the Treatment of Recurrent Gliomas

We investigated a therapeutic strategy for recurrent malignant gliomas using mesenchymal stem cells (MSC), expressing cytosine deaminase (CD), and prodrug 5-Fluorocytosine (5-FC) as a more specific and less toxic option. MSCs are emerging as a novel cell therapeutic agent with a cancer-targeting pro...

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Bibliographic Details
Published in:Theranostics
Main Authors: Chung, Taemoon, Na, Juri, Kim, Young-il, Chang, Da-Young, Kim, Young Il, Kim, Hyeonjin, Moon, Ho Eun, Kang, Keon Wook, Lee, Dong Soo, Chung, June-Key, Kim, Sung-Soo, Suh-Kim, Haeyoung, Paek, Sun Ha, Youn, Hyewon
Format: Artigo
Language:Inglês
Published: Ivyspring International Publisher 2016
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955049/
https://ncbi.nlm.nih.gov/pubmed/27446484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.14158
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