Inhibition of human tumor growth in mice by an oncolytic herpes simplex virus designed to target solely HER-2-positive cells

Oncolytic virotherapy exploits the ability of viruses to infect, replicate into, and kill tumor cells. Among the viruses that entered clinical trials are HSVs. HSVs can be engineered to become tumor-specific by deletion of selected genes or retargeting to tumor-specific receptors. A clinically relev...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Menotti, Laura, Nicoletti, Giordano, Gatta, Valentina, Croci, Stefania, Landuzzi, Lorena, De Giovanni, Carla, Nanni, Patrizia, Lollini, Pier-Luigi, Campadelli-Fiume, Gabriella
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2009
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684841/
https://ncbi.nlm.nih.gov/pubmed/19458262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812268106
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