Inhibition of human tumor growth in mice by an oncolytic herpes simplex virus designed to target solely HER-2-positive cells

Oncolytic virotherapy exploits the ability of viruses to infect, replicate into, and kill tumor cells. Among the viruses that entered clinical trials are HSVs. HSVs can be engineered to become tumor-specific by deletion of selected genes or retargeting to tumor-specific receptors. A clinically relev...

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Detalhes bibliográficos
Main Authors: Menotti, Laura, Nicoletti, Giordano, Gatta, Valentina, Croci, Stefania, Landuzzi, Lorena, De Giovanni, Carla, Nanni, Patrizia, Lollini, Pier-Luigi, Campadelli-Fiume, Gabriella
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684841/
https://ncbi.nlm.nih.gov/pubmed/19458262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812268106
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