Preclinical Therapy of Disseminated HER-2(+) Ovarian and Breast Carcinomas with a HER-2-Retargeted Oncolytic Herpesvirus

Oncolytic viruses aim to specifically kill tumor cells. A major challenge is the effective targeting of disseminated tumors in vivo. We retargeted herpes simplex virus (HSV) tropism to HER-2 oncoprotein p185, overexpressed in ovary and breast cancers. The HER-2-retargeted R-LM249 exclusively infects...

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Main Authors: Nanni, Patrizia, Gatta, Valentina, Menotti, Laura, De Giovanni, Carla, Ianzano, Marianna, Palladini, Arianna, Grosso, Valentina, Dall'Ora, Massimiliano, Croci, Stefania, Nicoletti, Giordano, Landuzzi, Lorena, Iezzi, Manuela, Campadelli-Fiume, Gabriella, Lollini, Pier-Luigi
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561254/
https://ncbi.nlm.nih.gov/pubmed/23382683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003155
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