Activation of p53-regulated pro-apoptotic signaling pathways in PrP-mediated myopathy

BACKGROUND: We have reported that doxycycline-induced over-expression of wild type prion protein (PrP) in skeletal muscles of Tg(HQK) mice is sufficient to cause a primary myopathy with no signs of peripheral neuropathy. The preferential accumulation of the truncated PrP C1 fragment was closely corr...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Liang, Jingjing, Parchaliuk, Debra, Medina, Sarah, Sorensen, Garrett, Landry, Laura, Huang, Shenghai, Wang, Meiling, Kong, Qingzhong, Booth, Stephanie A
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2009
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683871/
https://ncbi.nlm.nih.gov/pubmed/19400950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-10-201
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