PrP Conformational Transitions Alter Species Preference of a PrP-specific Antibody

The epitope of the 3F4 antibody most commonly used in human prion disease diagnosis is believed to consist of residues Met-Lys-His-Met (MKHM) corresponding to human PrP-(109–112). This assumption is based mainly on the observation that 3F4 reacts with human and hamster PrP but not with PrP from mous...

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Detalhes bibliográficos
Main Authors: Zou, Wen-Quan, Langeveld, Jan, Xiao, Xiangzhu, Chen, Shugui, McGeer, Patrick L., Yuan, Jue, Payne, Michael C., Kang, Hae-Eun, McGeehan, John, Sy, Man-Sun, Greenspan, Neil S., Kaplan, David, Wang, Gong-Xian, Parchi, Piero, Hoover, Edward, Kneale, Geoff, Telling, Glenn, Surewicz, Witold K., Kong, Qingzhong, Guo, Jian-Ping
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859550/
https://ncbi.nlm.nih.gov/pubmed/20194495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.088831
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