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Isolation of Soluble and Insoluble PrP Oligomers in the Normal Human Brain
The central event in the pathogenesis of prion diseases involves a conversion of the host-encoded cellular prion protein PrP(C) into its pathogenic isoform PrP(Sc 1). PrP(C) is detergent-soluble and sensitive to proteinase K (PK)-digestion, whereas PrP(Sc) forms detergent-insoluble aggregates and is...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MyJove Corporation
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3490312/ https://ncbi.nlm.nih.gov/pubmed/23070047 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/3788 |
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