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Activation of p53-regulated pro-apoptotic signaling pathways in PrP-mediated myopathy
BACKGROUND: We have reported that doxycycline-induced over-expression of wild type prion protein (PrP) in skeletal muscles of Tg(HQK) mice is sufficient to cause a primary myopathy with no signs of peripheral neuropathy. The preferential accumulation of the truncated PrP C1 fragment was closely corr...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2683871/ https://ncbi.nlm.nih.gov/pubmed/19400950 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-10-201 |
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