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Comparative Levels of O(6)-Methylguanine, Pyridyloxobutyl-, and Pyridylhydroxybutyl-DNA Adducts in Lung and Liver of Rats Treated Chronically with the Tobacco-Specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone

The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a lung carcinogen in rats and may be a cause of lung cancer in smokers. NNK is metabolized by cytochromes P450 to intermediates that react with DNA forming methyl, pyridyloxobutyl (POB), and pyridylhydroxybutyl...

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Autors principals: Upadhyaya, Pramod, Lindgren, Bruce R., Hecht, Stephen S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Pharmacology and Experimental Therapeutics 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683686/
https://ncbi.nlm.nih.gov/pubmed/19324941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.109.027078
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