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Structural and Functional Interaction between the Human DNA Repair Proteins DNA Ligase IV and XRCC4
Nonhomologous end-joining represents the major pathway used by human cells to repair DNA double-strand breaks. It relies on the XRCC4/DNA ligase IV complex to reseal DNA strands. Here we report the high-resolution crystal structure of human XRCC4 bound to the carboxy-terminal tandem BRCT repeat of D...
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| Hauptverfasser: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology (ASM)
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2682001/ https://ncbi.nlm.nih.gov/pubmed/19332554 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01895-08 |
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