Structural and Functional Interaction between the Human DNA Repair Proteins DNA Ligase IV and XRCC4

Nonhomologous end-joining represents the major pathway used by human cells to repair DNA double-strand breaks. It relies on the XRCC4/DNA ligase IV complex to reseal DNA strands. Here we report the high-resolution crystal structure of human XRCC4 bound to the carboxy-terminal tandem BRCT repeat of D...

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Main Authors: Wu, Peï-Yu, Frit, Philippe, Meesala, SriLakshmi, Dauvillier, Stéphanie, Modesti, Mauro, Andres, Sara N., Huang, Ying, Sekiguchi, JoAnn, Calsou, Patrick, Salles, Bernard, Junop, Murray S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682001/
https://ncbi.nlm.nih.gov/pubmed/19332554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01895-08
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