Structure-Based Virtual Ligand Screening on the XRCC4/DNA Ligase IV Interface

The association of DNA Ligase IV (Lig4) with XRCC4 is essential for repair of DNA double-strand breaks (DSBs) by Non-homologous end-joining (NHEJ) in humans. DSBs cytotoxicity is largely exploited in anticancer therapy. Thus, NHEJ is an attractive target for strategies aimed at increasing the sensit...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Menchon, Grégory, Bombarde, Oriane, Trivedi, Mansi, Négrel, Aurélie, Inard, Cyril, Giudetti, Brigitte, Baltas, Michel, Milon, Alain, Modesti, Mauro, Czaplicki, Georges, Calsou, Patrick
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786802/
https://ncbi.nlm.nih.gov/pubmed/26964677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22878
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