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Prion Protein Glycosylation Is Not Required for Strain-Specific Neurotropism

In this study, we tested the hypothesis that the glycosylation of the pathogenic isoform of the prion protein (PrP(Sc)) might encode the selective neurotropism of prion strains. We prepared unglycosylated cellular prion protein (PrP(C)) substrate molecules from normal mouse brain by treatment with P...

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Detaylı Bibliyografya
Asıl Yazarlar: Piro, Justin R., Harris, Brent T., Nishina, Koren, Soto, Claudio, Morales, Rodrigo, Rees, Judy R., Supattapone, Surachai
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology (ASM) 2009
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681931/
https://ncbi.nlm.nih.gov/pubmed/19297485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02502-08
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