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Modulation of the Oligomerization State of p53 by Differential Binding of Proteins of the S100 Family to p53 Monomers and Tetramers

We investigated the ways S100B, S100A1, S100A2, S100A4, and S100A6 bind to the different oligomeric forms of the tumor suppressor p53 in vitro, using analytical ultracentrifugation and multiangle light scattering. It is established that members of the S100 protein family bind to the tetramerization...

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Autors principals: van Dieck, Jan, Fernandez-Fernandez, Maria R., Veprintsev, Dmitry B., Fersht, Alan R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679481/
https://ncbi.nlm.nih.gov/pubmed/19297317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M901351200
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