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The Intracellular Juxtamembrane Domain of the Epidermal Growth Factor (EGF) Receptor Is Responsible for the Allosteric Regulation of EGF Binding

We have previously shown that the binding of epidermal growth factor (EGF) to its receptor can best be described by a model that involves negative cooperativity in an aggregating system (Macdonald, J. L., and Pike, L. J. (2008) Proc. Natl. Acad. Sci. U. S. A. 105, 112–117). However, despite the fact...

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Detalles Bibliográficos
Main Authors: Macdonald-Obermann, Jennifer L., Pike, Linda J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679458/
https://ncbi.nlm.nih.gov/pubmed/19336395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.001487
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