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The Intracellular Juxtamembrane Domain of the Epidermal Growth Factor (EGF) Receptor Is Responsible for the Allosteric Regulation of EGF Binding

We have previously shown that the binding of epidermal growth factor (EGF) to its receptor can best be described by a model that involves negative cooperativity in an aggregating system (Macdonald, J. L., and Pike, L. J. (2008) Proc. Natl. Acad. Sci. U. S. A. 105, 112–117). However, despite the fact...

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Bibliografske podrobnosti
Main Authors: Macdonald-Obermann, Jennifer L., Pike, Linda J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679458/
https://ncbi.nlm.nih.gov/pubmed/19336395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.001487
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