Dissecting the Mechanisms of Tissue Transglutaminase-induced Cross-linking of α-Synuclein: IMPLICATIONS FOR THE PATHOGENESIS OF PARKINSON DISEASE

Tissue transglutaminase (tTG) has been implicated in the pathogenesis of Parkinson disease (PD). However, exactly how tTG modulates the structural and functional properties of α-synuclein (α-syn) and contributes to the pathogenesis of PD remains unknown. Using site-directed mutagenesis combined with...

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Autores principales: Schmid, Adrien W., Chiappe, Diego, Pignat, Vérène, Grimminger, Valerie, Hang, Ivan, Moniatte, Marc, Lashuel, Hilal A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Protein Synthesis, Post-Translational Modification, and Degradation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676045/
https://ncbi.nlm.nih.gov/pubmed/19164286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809067200
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