Dissecting the Mechanisms of Tissue Transglutaminase-induced Cross-linking of α-Synuclein: IMPLICATIONS FOR THE PATHOGENESIS OF PARKINSON DISEASE

Tissue transglutaminase (tTG) has been implicated in the pathogenesis of Parkinson disease (PD). However, exactly how tTG modulates the structural and functional properties of α-synuclein (α-syn) and contributes to the pathogenesis of PD remains unknown. Using site-directed mutagenesis combined with...

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Autors principals: Schmid, Adrien W., Chiappe, Diego, Pignat, Vérène, Grimminger, Valerie, Hang, Ivan, Moniatte, Marc, Lashuel, Hilal A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
Matèries:
Protein Synthesis, Post-Translational Modification, and Degradation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676045/
https://ncbi.nlm.nih.gov/pubmed/19164286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809067200
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