Dissecting the Mechanisms of Tissue Transglutaminase-induced Cross-linking of α-Synuclein: IMPLICATIONS FOR THE PATHOGENESIS OF PARKINSON DISEASE

Tissue transglutaminase (tTG) has been implicated in the pathogenesis of Parkinson disease (PD). However, exactly how tTG modulates the structural and functional properties of α-synuclein (α-syn) and contributes to the pathogenesis of PD remains unknown. Using site-directed mutagenesis combined with...

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Detalhes bibliográficos
Main Authors: Schmid, Adrien W., Chiappe, Diego, Pignat, Vérène, Grimminger, Valerie, Hang, Ivan, Moniatte, Marc, Lashuel, Hilal A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676045/
https://ncbi.nlm.nih.gov/pubmed/19164286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809067200
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