Dissecting the Mechanisms of Tissue Transglutaminase-induced Cross-linking of α-Synuclein: IMPLICATIONS FOR THE PATHOGENESIS OF PARKINSON DISEASE

Tissue transglutaminase (tTG) has been implicated in the pathogenesis of Parkinson disease (PD). However, exactly how tTG modulates the structural and functional properties of α-synuclein (α-syn) and contributes to the pathogenesis of PD remains unknown. Using site-directed mutagenesis combined with...

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Hlavní autoři: Schmid, Adrien W., Chiappe, Diego, Pignat, Vérène, Grimminger, Valerie, Hang, Ivan, Moniatte, Marc, Lashuel, Hilal A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Protein Synthesis, Post-Translational Modification, and Degradation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676045/
https://ncbi.nlm.nih.gov/pubmed/19164286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809067200
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