The Serine Protease Plasmin Cleaves the Amino-terminal Domain of the NR2A Subunit to Relieve Zinc Inhibition of the N-Methyl-d-aspartate Receptors

Zinc is hypothesized to be co-released with glutamate at synapses of the central nervous system. Zinc binds to NR1/NR2A N-methyl-d-aspartate (NMDA) receptors with high affinity and inhibits NMDAR function in a voltage-independent manner. The serine protease plasmin can cleave a number of substrates,...

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Bibliographic Details
Main Authors: Yuan, Hongjie, Vance, Katie M., Junge, Candice E., Geballe, Matthew T., Snyder, James P., Hepler, John R., Yepes, Manuel, Low, Chian-Ming, Traynelis, Stephen F.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Mechanisms of Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676017/
https://ncbi.nlm.nih.gov/pubmed/19240037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805123200
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