Structural insights into phenylethanolamines high-affinity binding site in NR2B from binding and molecular modeling studies

BACKGROUND: Phenylethanolamines selectively bind to NR2B subunit-containing N-methyl-D-aspartate-subtype of ionotropic glutamate receptors and negatively modulate receptor activity. To investigate the structural and functional properties of the ifenprodil binding domain on the NR2B protein, we have...

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Detalhes bibliográficos
Main Authors: Ng, Fui-Mee, Geballe, Matthew T, Snyder, James P, Traynelis, Stephen F, Low, Chian-Ming
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2603005/
https://ncbi.nlm.nih.gov/pubmed/19017396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-6606-1-16
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