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Structural Determinants of d-Cycloserine Efficacy at the NR1/NR2C NMDA Receptors
We have studied relative efficacies of NR1 agonists glycine and d-cycloserine (DCS), and found efficacy to be dependent on the NR2 subunit. DCS shows partial agonism at NR1/NR2B but has higher relative efficacy than glycine at NR1/NR2C receptor. Molecular dynamics (MD) simulations of the NR1/NR2B an...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Society for Neuroscience
2010
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2862277/ https://ncbi.nlm.nih.gov/pubmed/20164358 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5390-09.2010 |
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