Structural Determinants of d-Cycloserine Efficacy at the NR1/NR2C NMDA Receptors

We have studied relative efficacies of NR1 agonists glycine and d-cycloserine (DCS), and found efficacy to be dependent on the NR2 subunit. DCS shows partial agonism at NR1/NR2B but has higher relative efficacy than glycine at NR1/NR2C receptor. Molecular dynamics (MD) simulations of the NR1/NR2B an...

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Main Authors: Dravid, Shashank M., Burger, Pieter B., Prakash, Anand, Geballe, Matthew T., Yadav, Roopali, Le, Phuong, Vellano, Kimberly, Snyder, James P., Traynelis, Stephen F.
格式: Artigo
語言:Inglês
出版: Society for Neuroscience 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862277/
https://ncbi.nlm.nih.gov/pubmed/20164358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5390-09.2010
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