Plasmin Potentiates Synaptic N-Methyl-D-aspartate Receptor Function in Hippocampal Neurons through Activation of Protease-activated Receptor-1

Protease-activated receptor-1 (PAR1) is activated by a number of serine proteases, including plasmin. Both PAR1 and plasminogen, the precursor of plasmin, are expressed in the central nervous system. In this study we examined the effects of plasmin in astrocyte and neuronal cultures as well as in hi...

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Detalhes bibliográficos
Main Authors: Mannaioni, Guido, Orr, Anna G., Hamill, Cecily E., Yuan, Hongjie, Pedone, Katherine H., McCoy, Kelly L., Palmini, Rolando Berlinguer, Junge, Candice E., Lee, C. Justin, Yepes, Manuel, Hepler, John R., Traynelis, Stephen F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2459301/
https://ncbi.nlm.nih.gov/pubmed/18474593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803015200
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