Plasmin Potentiates Synaptic N-Methyl-D-aspartate Receptor Function in Hippocampal Neurons through Activation of Protease-activated Receptor-1

Protease-activated receptor-1 (PAR1) is activated by a number of serine proteases, including plasmin. Both PAR1 and plasminogen, the precursor of plasmin, are expressed in the central nervous system. In this study we examined the effects of plasmin in astrocyte and neuronal cultures as well as in hi...

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Hlavní autoři: Mannaioni, Guido, Orr, Anna G., Hamill, Cecily E., Yuan, Hongjie, Pedone, Katherine H., McCoy, Kelly L., Palmini, Rolando Berlinguer, Junge, Candice E., Lee, C. Justin, Yepes, Manuel, Hepler, John R., Traynelis, Stephen F.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2008
Témata:
Mechanisms of Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2459301/
https://ncbi.nlm.nih.gov/pubmed/18474593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803015200
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