Plasmin Potentiates Synaptic N-Methyl-D-aspartate Receptor Function in Hippocampal Neurons through Activation of Protease-activated Receptor-1

Protease-activated receptor-1 (PAR1) is activated by a number of serine proteases, including plasmin. Both PAR1 and plasminogen, the precursor of plasmin, are expressed in the central nervous system. In this study we examined the effects of plasmin in astrocyte and neuronal cultures as well as in hi...

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Autores principales: Mannaioni, Guido, Orr, Anna G., Hamill, Cecily E., Yuan, Hongjie, Pedone, Katherine H., McCoy, Kelly L., Palmini, Rolando Berlinguer, Junge, Candice E., Lee, C. Justin, Yepes, Manuel, Hepler, John R., Traynelis, Stephen F.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Materias:
Mechanisms of Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2459301/
https://ncbi.nlm.nih.gov/pubmed/18474593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803015200
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