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Solution structure of DNA containing α-OH-PdG: the mutagenic adduct produced by acrolein
Acrolein is a cell metabolic product and a main component of cigarette smoke. Its reaction with DNA produces two guanine lesions γ-OH-PdG, a major adduct that is nonmutagenic in mammalian cells, and the positional isomer α-OH-PdG. We describe here the solution structure of a short DNA duplex contain...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2673425/ https://ncbi.nlm.nih.gov/pubmed/19223332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp076 |
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