Structure and stability of DNA containing an aristolactam II-dA lesion: implications for the NER recognition of bulky adducts

Aristolochic acids I and II are prevalent plant toxicants found in the Aristolochiaceae plant family. Metabolic activation of the aristolochic acids leads to the formation of a cyclic N-hydroxylactam product that can react with the peripheral amino group of purine bases generating bulky DNA adducts....

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Bibliographic Details
Main Authors: Lukin, Mark, Zaliznyak, Tanya, Johnson, Francis, de los Santos, Carlos
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
Subjects:
Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315293/
https://ncbi.nlm.nih.gov/pubmed/22121223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1094
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