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Structure and stability of DNA containing an aristolactam II-dA lesion: implications for the NER recognition of bulky adducts
Aristolochic acids I and II are prevalent plant toxicants found in the Aristolochiaceae plant family. Metabolic activation of the aristolochic acids leads to the formation of a cyclic N-hydroxylactam product that can react with the peripheral amino group of purine bases generating bulky DNA adducts....
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3315293/ https://ncbi.nlm.nih.gov/pubmed/22121223 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1094 |
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