Solution Structure of Duplex DNA Containing a β-Carba-Fapy-dG Lesion

The addition of hydroxyl radicals to the C8 position of guanine can lead to the formation of 2,6-diamino-4-hydroxy-5-formamido-2′-deoxypyrimidine (Fapy-dG) lesion, whose endogenous levels in cellular DNA rival those of 8-oxo-7,8-dihydroxy-2′-deoxyguanosine. Despite its prevalence, the structure of d...

Full description

Saved in:
Bibliographic Details
Main Authors: Lukin, Mark, Zaliznyak, Tatiana, Attaluri, Sivaprasad, Johnson, Francis, de los Santos, Carlos
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3502696/
https://ncbi.nlm.nih.gov/pubmed/22897814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx300290b
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items