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Solution Structure of Duplex DNA Containing a β-Carba-Fapy-dG Lesion
The addition of hydroxyl radicals to the C8 position of guanine can lead to the formation of 2,6-diamino-4-hydroxy-5-formamido-2′-deoxypyrimidine (Fapy-dG) lesion, whose endogenous levels in cellular DNA rival those of 8-oxo-7,8-dihydroxy-2′-deoxyguanosine. Despite its prevalence, the structure of d...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3502696/ https://ncbi.nlm.nih.gov/pubmed/22897814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx300290b |
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