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NMR Structure of Duplex DNA Containing the α-OH-PdG•dA Base Pair: a Mutagenic Intermediate of Acrolein
Acrolein, a cell metabolic product and main component of cigarette smoke, reacts with DNA generating α-OH-PdG lesions, which have the ability to pair with dATP during replication thereby causing G to T transversions. We describe the solution structure of an 11-mer DNA duplex containing the mutagenic...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3008548/ https://ncbi.nlm.nih.gov/pubmed/20049919 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bip.21366 |
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