Solution structure of DNA containing α-OH-PdG: the mutagenic adduct produced by acrolein

Acrolein is a cell metabolic product and a main component of cigarette smoke. Its reaction with DNA produces two guanine lesions γ-OH-PdG, a major adduct that is nonmutagenic in mammalian cells, and the positional isomer α-OH-PdG. We describe here the solution structure of a short DNA duplex contain...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Zaliznyak, Tanya, Bonala, Rahda, Attaluri, Sivaprasad, Johnson, Francis, de los Santos, Carlos
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2009
Gaiak:
Structural Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673425/
https://ncbi.nlm.nih.gov/pubmed/19223332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp076
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