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Ring-Opening of the γ-OH-PdG Adduct Promotes Error-Free Bypass by the Sulfolobus solfataricus DNA Polymerase Dpo4
[Image: see text] Acrolein, a mutagenic aldehyde, reacts with deoxyguanosine (dG) to form 3-(2′-deoxy-β-d-erythro-pentofuranosyl)-5,6,7,8-tetrahydro-8-hydroxypyrimido[1,2-a] purin-10(3H)-one (γ-OH-PdG). When placed opposite deoxycytosine (dC) in DNA, γ-OH-PdG undergoes ring-opening to the N(2)-(3-ox...
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| Main Authors: | , , , , , , , , |
|---|---|
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
American
Chemical Society
2013
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| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3775444/ https://ncbi.nlm.nih.gov/pubmed/23947567 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx400200b |
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