Ring-Opening of the γ-OH-PdG Adduct Promotes Error-Free Bypass by the Sulfolobus solfataricus DNA Polymerase Dpo4

[Image: see text] Acrolein, a mutagenic aldehyde, reacts with deoxyguanosine (dG) to form 3-(2′-deoxy-β-d-erythro-pentofuranosyl)-5,6,7,8-tetrahydro-8-hydroxypyrimido[1,2-a] purin-10(3H)-one (γ-OH-PdG). When placed opposite deoxycytosine (dC) in DNA, γ-OH-PdG undergoes ring-opening to the N(2)-(3-ox...

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Detalhes bibliográficos
Main Authors: Shanmugam, Ganesh, Minko, Irina G., Banerjee, Surajit, Christov, Plamen P., Kozekov, Ivan D., Rizzo, Carmelo J., Lloyd, R. Stephen, Egli, Martin, Stone, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3775444/
https://ncbi.nlm.nih.gov/pubmed/23947567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx400200b
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