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Bypass of Aflatoxin B(1) Adducts by the Sulfolobus solfataricus DNA Polymerase IV
[Image: see text] Aflatoxin B(1) (AFB(1)) is oxidized to an epoxide in vivo, which forms an N7-dG DNA adduct (AFB(1)–N7-dG). The AFB(1)–N7-dG can rearrange to a formamidopyrimidine (AFB(1)–FAPY) derivative. Both AFB(1)–N7-dG and the β-anomer of the AFB(1)–FAPY adduct yield G→T transversions in Esche...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3154525/ https://ncbi.nlm.nih.gov/pubmed/21790157 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja2015668 |
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