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Structural Basis for Error-Free Bypass of the N7-Methyl-Formamidopyrimidine-dG Lesion by Human DNA Polymerase η and Sulfolobus solfataricus P2 Polymerase IV (Dpo4)
2,6-Diamino-4-hydroxy-5N-methylformamidopyrimidine (MeFapy-dG) arises from N7-methylation of guanine followed by imidazole ring opening. The lesion has been reported to persist in animal tissues. Previous in vitro replication bypass investigations of the MeFapy-dG adduct revealed predominant inserti...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4545269/ https://ncbi.nlm.nih.gov/pubmed/25988947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b02701 |
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